Systems Engineering and Pathophysiology

Submitted by jacklyn.ebiasah on Fri, 03/13/2020 - 10:26
Rajanikanth Vadigepalli

Rajanikanth Vadigepalli

Vice Chair of Research and a Professor of Pathology, Anatomy and Cell Biology at Thomas Jefferson University, Philadelphia

Laboratory page: https://research.jefferson.edu/labs/researcher/vadigepalli-laboratory.html

(also see: https://www.researchgate.net/profile/Rajanikanth_Vadigepalli)

Dr. Vadigepalli’s collaborative research program at the Daniel Baugh Institute for Functional Genomics/Computational Biology is driven by a convergence of systems engineering, computational modeling, bioinformatics, and single cell scale transcriptomics, to identify and target key control points for intervention in disease.

Ongoing collaborative projects:

  • central and peripheral neural circuits and microRNA networks regulating hypertension and heart failure
  • multiscale networks controlling liver regeneration and tissue repair
  • systems biology of alcoholic liver disease
  • systems ontogeny of developmental defects

Recent research from the group has led to:

IMAG related activities: Dr. Vadigepalli is a member of the Committee on Credible Practice of Modeling & Simulation in Healthcare, and is developing guidelines and best practices for building and documenting computational models in healthcare. He co-leads the Computational Neuroscience Working Group of the Multiscale Modeling Consortium.

Contact: rajanikanth.vadigepalli@jefferson.edu

 

Tags
systems biology
genomic pathology
transcriptomics
dynamic modeling
machine learning
single cell analysis
high throughput techniques
computational neuroscience
physiology
cardiovascular control
liver regeneration
developmental defects
stem cells