Systems Engineering and Pathophysiology

Submitted by jacklyn.ebiasah on Fri, 03/13/2020 - 10:26
Rajanikanth Vadigepalli

Rajanikanth Vadigepalli

Vice Chair of Research and a Professor of Pathology, Anatomy and Cell Biology at Thomas Jefferson University, Philadelphia

Laboratory page:

(also see:

Dr. Vadigepalli’s collaborative research program at the Daniel Baugh Institute for Functional Genomics/Computational Biology is driven by a convergence of systems engineering, computational modeling, bioinformatics, and single cell scale transcriptomics, to identify and target key control points for intervention in disease.

Ongoing collaborative projects:

  • central and peripheral neural circuits and microRNA networks regulating hypertension and heart failure
  • multiscale networks controlling liver regeneration and tissue repair
  • systems biology of alcoholic liver disease
  • systems ontogeny of developmental defects

Recent research from the group has led to:

IMAG related activities: Dr. Vadigepalli is a member of the Committee on Credible Practice of Modeling & Simulation in Healthcare, and is developing guidelines and best practices for building and documenting computational models in healthcare. He co-leads the Computational Neuroscience Working Group of the Multiscale Modeling Consortium.



systems biology
genomic pathology
dynamic modeling
machine learning
single cell analysis
high throughput techniques
computational neuroscience
cardiovascular control
liver regeneration
developmental defects
stem cells