Vice Chair of Research and a Professor of Pathology, Anatomy and Cell Biology at Thomas Jefferson University, Philadelphia
Dr. Vadigepalli’s collaborative research program at the Daniel Baugh Institute for Functional Genomics/Computational Biology is driven by a convergence of systems engineering, computational modeling, bioinformatics, and single cell scale transcriptomics, to identify and target key control points for intervention in disease.
Ongoing collaborative projects:
- central and peripheral neural circuits and microRNA networks regulating hypertension and heart failure
- multiscale networks controlling liver regeneration and tissue repair
- systems biology of alcoholic liver disease
- systems ontogeny of developmental defects
Recent research from the group has led to:
- a comprehensive 3D anatomical and molecular map of the intrinsic cardiac nervous system (biorxiv)
- new microRNA-based molecular targets to prevent essential hypertension (omics; interventions)
- novel insights into the process of liver regeneration paving the way for new clinical decision-making tools (e.g., human liver resection; human liver failure; multiscale network; cellular model)
- new statistical tools for mining high-dimensional data (e.g., COMPACT; SPSNet)
- novel computational methods for multiscale modeling of gene regulatory networks (e.g., information theory; multi-organ; causality)
IMAG related activities: Dr. Vadigepalli is a member of the Committee on Credible Practice of Modeling & Simulation in Healthcare, and is developing guidelines and best practices for building and documenting computational models in healthcare. He co-leads the Computational Neuroscience Working Group of the Multiscale Modeling Consortium.