IMAG/MSM WG Multiscale Modeling and Viral Pandemics Zoom
To join the meeting:
Please feel free to forward this invitation on to anyone you think would be interested.
Thursday June 23 at 3:00PM (EST)
The schedule for this week consists of one presentation:
1. Fiona MacFarlane, St Andrew University. A single-cell mathematical model of SARS-CoV-2 induced pyroptosis: Pyroptosis is an inflammatory mode of cell death that can contribute to the cytokine storm associated with severe cases of coronavirus disease 2019 (COVID-19). The formation of the NLRP3 inflammasome is central to pyroptosis, which may be induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Inflammasome formation, and by extension pyroptosis, may be inhibited by certain anti-inflammatory drugs. In this study, we present a single-cell mathematical model that captures the formation of the NLRP3 inflammasome, pyroptotic cell death and responses to anti-inflammatory intervention that hinder the formation of the NLRP3 inflammasome. Our results demonstrate that an anti-inflammatory drug can delay the formation of the NLRP3 inflammasome, and thus may alter the mode of cell death from inflammatory (pyroptosis) to non-inflammatory (e.g., apoptosis). The single-cell model is further implemented at a multicellular level within a SARS-CoV-2 tissue simulator in collaboration with a multidisciplinary coalition investigating within host-dynamics of COVID-19.
After the presentations we will have breakout rooms for each of the speakers where you may discuss technical questions.