COPYRIGHT AND REQUEST FOR ACKNOWLEDGMENT OF USE: Copyright (C) 1999-2020 University of Washington. From the National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061. Unless noted in individual model, all models are open access and distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. When citing JSim please use this reference: Butterworth E, Jardine BE, Raymond GM, Neal ML, Bassingthwaighte JB. JSim, an open-source modeling system for data analysis [v3; ref status: indexed, http://f1000r.es/3n0] F1000Research 2014, 2:288 (doi: 10.12688/f1000research.2-288.v3) Models and software were developed with support from NIH grants HL088516 and HL073598, NIBIB grant BE08417, the Cardiac Energy Grid HL122199 (PI: J.B. Bassingthwaighte), and the Virtual Physiological Rat program GM094503 (PI: D.A.Beard). Please cite these grants in any publication for which this model or software software is used.