MODEL NUMBER: 0246 MODEL NAME: Comp2ExchangeReaction SHORT DESCRIPTION: Two comparment model with two substances, A and B, and where A may be irreversibly converted to B. END OF MODEL FIGURE: +-----------+ +-----------+ | G1 | PSa | G2 | | A1---->B1 |<-------->| A2---->B2 | | V1 | PSb | V2 | +-----------+ +-----------+ DETAILED DESCRIPTION: This is a two compartment model for two substances, A and B. Both substances can passively move from one compartment to the other. A is irreversibly converted to B in either or both compartments. KEY WORDS: Course, compartment, compartmental, tutorial, exchange, multiple compartments, flux, steady state, reaction, conversion REFERENCES: None. REVISION HISTORY: JBB: Equilibrium(t) changed to a function of time. 6apr2012 JSim SOFTWARE COPYRIGHT AND REQUEST FOR ACKNOWLEDGMENT OF USE: JSim software was developed with support from NIH grants HL088516, and HL073598. Please cite these grants in any publication for which this software is used and send one reprint of published abstracts or articles to the address given below. Academic use is unrestricted. Software may be copied so long as this copyright notice is included. Copyright (C) 1999-2012 University of Washington. Contact Information: The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle, WA 98195-5061

concentration of A in compartment 2

concentration of A in compartment 1

Conversion rate of A to B in compartment 2

Conversion rate of A to B in compartment 1

initial concentration of B in compartment 1

volume of compartment 2

volume of compartment 1

concentration of B in compartment 2

concentration of B in compartment 1

Permeability Surface area product

Permeability Surface area product

Equilibrium concentration for B if G>0

initial concentration of B in compartment 2

initial concentration of A in compartment 1

initial concentration of A in compartment 2

initial concentration of B in compartment 2

initial concentration of A in compartment 1

initial concentration of A in compartment 2

initial concentration of B in compartment 1

Mass balance check