Title: Constructing a mechanistic, multi-level, multi-organ and multi-time scale digital twin: key data validations, features, and lessons learned
Over 20 years, we have collaborated with a large number of clinical and experimental experts to develop different state-of-the-art mechanistic models for the main organs in the human body: the liver, brain, heart, adipose tissue, blood vessels, etc. Recently, these models have been merged together into an interconnected model, with cross-talk between all organs, and with successful validation simulations on both short (seconds and minutes) and long (weeks, months, and years) timescales. We have also used a new hybrid modelling approach, for both risk calculations and simulations, to be able to simulate and test disease-, diet-, and medication-scenarios for a first digital twin, based on a large number of measurements from a specific person. In this talk, I will both show some of the main features, and talk about some of the main lessons learned, when building this new modelling technology, which also includes a first beta-version of an interface to be used by non-experts, like physicians and patients. I will also outline our plans for converting these models into a joint open-science, modular project where groups can collaborate, discuss and contribute with their own models and data, to help improve consensus-building and reproducibility in biomedical research and applications.
Prof. Cedersund has his basic training in theoretical physics, but has been working for 20 years with mathematical modelling of biomedical systems, first in engineering departments, and then in cell biology, clinical, and biomedical engineering departments. The modeling projects has covered almost all of the main organs in human body: the liver, brain, fat tissue, pancreas, heart and blood circulation, muscle, spleen, etc. Lately, these have come together into a single interconnected multi-level and multi-timescale model for the whole-body. This model interconnects brain activity with inflammation, blood flow and pressure control, with fat and glucose metabolism, etc. This integrative work is possible via the joint and coordinated action of the 15 people strong research group called “Integrative Systems Biology”, located in Linköping, Sweden. To help commercialize and productify the resulting digital twin technology, Cedersund has recently started the new spin-off company “SUND sound medical decisions”.
10/23/19 YouTube re-recording for ML-MSM meeting
Previously recorded presentation in YouTube.