NIGMS

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Funding Opportunities

  • NIGMS National Centers for Systems Biology (P50)

NIGMS MSM-related specific Challenge Topic

For a complete listing of NIGMS Challenge Topics, http://www.nigms.nih.gov/recovery/


NIGMS Broad Challenge Areas and Specific Challenge Topics

01-GM-101 Individual-based model of social behavior. Development of a robust and well-characterized individual-based model of social behavior that includes the dynamics of social interactions and that matches observed patterns of behavior. Contact: Dr. Irene Eckstrand, 301-594-0943, eckstrai@nigms.nih.gov

01-GM-103 Formation and evolution of social organization. Development of pilot projects to demonstrate how virtual or e-communities may provide information and insights into the formation and evolution of social organization. Contact: Dr. Irene Eckstrand, 301-594-0943, eckstrai@nigms.nih.gov

06-GM-114 Microbial sequence annotation. Development of new approaches to the rapid and comprehensive annotation of microbial sequences resulting from metagenomics and other high-capacity outputs. Approaches may combine high-throughput experimental methods with innovative data mining algorithms and model building. Contact: Dr. James Anderson, 301-594-0943, andersoj@nigms.nih.gov

06-GM-115 High-end computing software. Upgrading of biomedical computing software to high-end computing (HEC). This developmental effort will seek to expand the domain areas to the macromolecular, cell, tissue, organ, whole-organism, and population levels. The program would support grants to upgrade and port software to run and perform experiments on new generation HEC supercomputers. Contact: Dr. Peter Lyster, 301-594-3928, lysterp@mail.nih.gov

04-GM-101 Personalized drug response and toxicity. Application of pharmacogenetics and pharmacogenomics, quantitative and systems pharmacology (this could be part of a larger grouping to include systems biology and systems genetics), ADMET pharmacology, preclinical models, and new technologies and approaches to complement pharmacogenomic studies to enhance signal-to-noise ratios and aid mechanistic studies, and consensus standards for normal and altered phenotypes in drug response and toxicity. Contact: Dr. Rochelle Long, 301-594-3827, longr@nigms.nih.gov; Dr. Richard Okita, 301-594-3827, okitar@nigms.nih.gov; NIAMS Contact: Dr. Susana Serrate-Sztein, 301-594-5032, NIAMShelp-NIHChallengeGrants@mail.nih.gov

06-GM-101 Structural analysis of macromolecular complexes. Development of new approaches, technologies, and reagents that would facilitate functional and/or structural analysis of macromolecular complexes. Contacts: Dr. Ravi Basavappa, 301-594-0828, basavapr@nigms.nih.gov; Dr. Laurie Tompkins, 301-594-0943, tompkinl@nigms.nih.gov

06-GM-102 Chemist/biologist collaborations facilitating tool development. Development of chemical probes, imaging agents, radiochemicals, and other tools for understanding biology through collaborations between a chemist(s) and a biologist(s). Contacts: Dr. James Deatherage, 301-594-0828, deatherj@nigms.nih.gov; Dr. Michael Rogers, 301-594-3827, rogersm@nigms.nih.gov

06-GM-103 Development of predictive methods for molecular structure, recognition, and ligand interaction. Studies to more precisely predict molecular structure and interactions between molecules and ligands to lay the foundation for a new generation of therapeutics and drug design. Powerful predictive methods will require the acquisition of experimentally derived constraints and breakthrough computational methods. Reliable, high-throughput predictive methods would create a more comprehensive resource for understanding molecular interaction that would eventually replace the use of slower, empirical determinations. Contacts: Dr. Peter Preusch, 301-594-0828,preuschp@nigms.nih.gov; Dr. Warren Jones, 301-594-3827, jonesw@nigms.nih.gov

06-GM-104 Dynamics of membrane structure and function. Development of new technology to study the dynamics of membrane structure and function to better understand how membrane components change as they sense the environment, assemble, or bind metabolites. Contact: Dr. Jean Chin, 301-594-0828, chinj@nigms.nih.gov

06-GM-105 Small RNAs. Identification and functional characterization of all classes of small RNAs, to elucidate their regulation and mechanism of action and to understand their evolutionary origin. Contact: Dr. Michael Bender, 301-594-0943, bendermt@nigms.nih.gov

06-GM-106 Subcellular imaging of metal ions. Development of metallobiochemistry methods to image metal ions and metal ion species at the subcellular level. Contact: Dr. Vernon Anderson, 301-594-3827, andersonve@nigms.nih.gov 06-GM-107 Metal ion binding and function. Development of high-throughput methods for the prediction of metal ion binding and function in proteins at the structural, redox, and/or catalytic levels. Contact: Dr. Vernon Anderson, 301-594-3827, andersonve@nigms.nih.gov

06-GM-108 Functions of glycan-binding proteins. Creation of new, high-throughput methods for deciphering the biological functions of glycan-binding proteins. Contact: Dr. Pamela Marino, 301-594-3827, marinop@nigms.nih.gov

06-GM-109 Green chemistry and engineering for drug discovery, development, and production. Development of chemical methodologies and tools to promote green chemistry and engineering innovation into drug discovery, development, and production. Contact: Dr. Miles Fabian, 301-594-3827, fabianm@nigms.nih.gov

06-GM-110 Synthesis, structure, and function of glycans. Development of new approaches, technologies, reagents, and tools to facilitate understanding of the synthesis, structure, and function of glycans. Contact: Dr. Pamela Marino, 301-594-3827, marinop@nigms.nih.gov

06-GM-112 Molecular and cellular dynamics technologies. Development of tools, reagents, and technologies to better understand molecular and cellular dynamics in vivo. The goal is to develop the capability to characterize the abundance, location, composition, interactions, and turnover of individual molecules with high sensitivity and with little perturbation of the cellular environment. New methods, including those for single-molecule resolution, are needed for tracking and recording these changes in vivo at the subcellular level. Contact: Dr. Catherine Lewis, 301-594-0828, lewisc@nigms.nih.gov

06-GM-113 Structural analysis of large cellular components and organelles. Development of hybrid methods to enable the structural analysis of large cellular components and organelles. This will enable the determination of structures that are not amenable to routine X-ray crystallography or NMR spectroscopy. The new methods will make use of combined, “hybrid” data from a variety of sources as well as computational methods to integrate data sources using a range of dimensions, scales, and formats. Contact: Dr. Ravi Basavappa, 301-594-0828, basavapr@nigms.nih.gov

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