Sensory motor transformations in human cortex | Interagency Modeling and Analysis Group

Investigator Names	Richard Andersen, Vasileios Christopoulos, Charles Liu
Institutions	California Institute of Technology, University of California, Riverside, University of Southern California, Rancho Los Amigos Rehabilitation Center
Grant support:	NIH BRAIN, U01NS123127
Performance period	Aug 2021 – July 2026

Goal: We will explore, for the first time at the fine scale of single neuron populations, the coordinate frame representations and dynamics for movement intentions and world-state representations, the relationship between artificial somatosensory sensations introduced by intracortical microstimulation (ICMS) and imagined sensations in primary somatosensory cortex (S1) and PPC, and internal-model learning. These studies will provide new knowledge of the functioning of human cortex in sensorimotor integration and will guide the further development of cognitive neural prosthetics.

Study population and setting:

•Participants include tetraplegic individuals with high cervical spinal lesion who are surgically cleared to have an intracortical sensorimotor brain-computer interface implanted as part of clinical trial NCT01964261.

•The study is conducted under an FDA Investigational Device Exemption utilizing the Neuroport Array.

Data generated:

•Intracortical recordings and stimulation parameters along with behavioral and task-related data will be archived on DABI.

Resources:

https://www.vis.caltech.edu https://clinicaltrials.gov/ct2/home

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