National Institute of Health

Notice of Special Interest (NOSI): Administrative Supplements to Support the Development of Digital Twins in Radiation Oncology (DTRO)

The Division of Cancer Treatment and Diagnosis (DCTD) and the Center for Biomedical Informatics and Information Technology (CBIIT) at the National Cancer Institute (NCI) announce the Digital Twins Radiation Oncology (DTRO) administrative supplement opportunity that seeks to support collaborative, multidisciplinary research in radiation oncology in the development of digital twins. For the purposes of this notice, a digital twin as defined by the 

NIH NOITP: Understanding the Intersection of Social Inequities to Optimize Health and Reduce Health Disparities: The Axes Initiative

Notice of Intent to Publish a Funding Opportunity Announcement for Understanding the Intersection of Social Inequities to Optimize Health and Reduce Health Disparities: The Axes Initiative (R01 Clinical Trial Optional)



Multi-Scale Models Bridging Levels of Analysis in Aging and Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (R01 Clinical Trial Not Allowed)

This notice of funding opportunity (NOFO) invites applications proposing to establish multi-scale computational models recapitulating dynamic changes associated with aging and Alzheimer’s disease (AD) and AD-related dementias (ADRD). This broad scope encompasses a variety of computational approaches—such as mathematical and computational modeling, image analysis, artificial intelligence, and machine learning—to better understand aging processes and AD/ADRD across molecules, cells and networks, and cognition and behavior. 

BRAIN Initiative: Brain-Behavior Quantification and Synchronization – Transformative and Integrative Models of Behavior at the Organismal Level (R34 Clinical Trial Optional)

This notice of funding opportunity (NOFO) seeks applications proposing a set of planning activities that will lay the groundwork for a scientific project aimed at integrating complementary theories and methods to 1) develop, validate, and apply cutting-edge tools and methods for minimally invasive, multi-dimensional, high-resolution measurement of behavior at the level of the organism, with synchronous capture of changes in the organism’s social or physical environment; and 2) develop data science and computational methods that allow for integration of multidimensional behavioral and enviro

BRAIN Initiative: Brain Behavior Quantification and Synchronization (R61/R33 Clinical Trial Optional)

This Funding Opportunity Announcement (FOA) supports the development and validation of next-generation tools, methods, and analytic approaches to precisely quantify behaviors and combine them with simultaneous recordings of brain activity in humans. Tools used for measuring and analyzing behavior should be multi-modal, with the appropriate accuracy, specificity, temporal resolution, and flexibility necessary for integration with existing tools used to measure and modulate the brain circuits that give rise to those behaviors.

Notice of Special Interest (NOSI): BRAIN Initiative: Mentored Clinician Scientist Research Career Development program to Develop Expertise in Intracranial Human Neuroscience Research (K08)

The purpose of this Notice of Special Interest (NOSI) is to promote the availability of Mentored Clinician Scientist Research Career Development Awards (K08) applications in research areas covered by the NIH BRAIN Initiative®. This program will provide support and protected time (3-5 years) for clinicians to develop new and/or expand their expertise in intracranial human neuroscience research.