What exactly is Multiscale Modeling??

Current IMAG definition:

Multiscale, biomedical modeling uses mathematics and computation to represent and simulate a physiological system at more than one biological scale. Biological scales include atomic, molecular, molecular complexes, sub-cellular, cellular, multi-cell systems, tissue, organ, multi-organ systems, organism, population, and behavior. These multiscale biomedical models may also include dynamical processes which span multiple time and length scales.

Comments

Grids

Computational continuum physics is fast becoming an important part of biomedical research. Typically, the geometries for biomedical problems are derived from medical imaging modalities such as magnetic resonance imaging (MRI), and are geometrically complex compared to many engineering problems. Efficient unstructured mesh generation of these geometries remains challenging. Several excellent isotropic unstructured tetrahedral grid generation algorithms exist for creating finite-element or finite-volume grids from imaging-derived closed triangulated manifolds [1-3].

Computational Biomechanics Tools

Multibody Dynamics

Branch of computational mechanics that includes both rigid and flexible bodies. The flexible elements are represented with springs and dampers. Multi-body dynamics involves structural dynamics, mechanics, computational mathematics, and control theory. It is the computational method typically used in movement simulation and neuromusculoskeletal models. Solutions involve algebraic and ordinary differential equations.

Working Group 1 Participants

Active Participants:

Victor Barocas, University of Minnesota - Twin Cities

Roger Kamm, Massachusetts Institute of Technology

George Karniadakis, Brown University

Anthony Ladd, University of Florida

Peter Ortoleva, Indiana University

Jay Schieber, Illinois Institute of Technology

 

Observers:

Jim Brasseur, Pennsylvania State University

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