The Stimulating Peripheral Activities to Relieve Conditions (SPARC) Data and Resource Center, with funding from the National Institutes of Health, is hosting an in-the-cloud codeathon from July 12-26, 2021. Submissions for project proposals are due May 10, 2021.
Eligibility: Competitors from the United States and abroad are eligible.
Prizes Available: Several prizes of up to US$10,000 each will be awarded.
Background
With multiple COVID-19 vaccines available, understanding the epidemiologic, clinical, and economic value of increasing coverage levels and expediting vaccination is important.
Methods
We developed a computational model (transmission and age-stratified clinical and economics outcome model) representing the US population, COVID-19 coronavirus spread (02/2020-12/2022), and vaccination to determine the impact of increasing coverage and expediting time to achieve coverage.
Results
Most patients who develop heart failure are unable to elevate their cardiac output on demand due to impaired contractility and/or reduced ventricular filling. Despite decades of research, few effective therapies for heart failure have been developed. In part, this may reflect the difficulty of predicting how perturbations to molecular-level mechanisms that are induced by drugs will scale up to modulate system-level properties such as blood pressure. Computer modeling might help with this process and thereby accelerate the development of better therapies for heart failure.
