The Physiome.org website, host of the National Simulation Resource for Circulatory Mass Transport and Exchange (NSR Physiome Project), has changed its location and its sponsor: having been supported by multiple institutes at the National Institutes of Health (NIH) for the past four decades at the University of Washington, UW, in Seattle WA, it is now hosted in Washington DC at the NIH/National Institute for Bioimaging and Bioengineering managed by the Interagency Modeling and Analysis Group (IMAG) under the leadership of Grace Peng, PhD, Director.

We want to know what you think of this site. Please send comments, questions, or suggestions for improvements to:

Scientific/Research

Bart Jardine: Acting Physiome Coordinator
Phone: 206-685-2006
Email: barthj@u.washington.edu

NSR Course info, Models, and Publications

Bart Jardine
Phone: 206-685-2006;
Email: barthj@u.washington.edu

• Circulatory resistances constant, independant of volume (except Vena cava and systemic arteries).
• Blood viscosity constant, independent of vessel volume.
• Vessel walls strictly elastic, not visco-elastic (except aorta and pulmonary artery.
• Governing equation for baroreception based on experiments with dog carotid sinus only; proximal aortic pressure is used as the input for the baroreceptor's governing equation.
• We used a discrete heart rate and contractility function. Without this function heartbeats get interrupted and become erratic.

• No aortic valve resistance listed in Lu et al. (2001). We used a low valve resistance (tricuspid) for this parameter. Note: Tricuspid resistance listed as "Rta" in Glossary of publication is not listed in Table 4.
• Using the values listed in Table 5 of Lu et al. (2001), we plotted Pvc vs. Vvc after running the syscirc model for several cardiac cycles. There was a discontinuity in this graph when Vvc = Vo (Vena cava volume = unstressed Vena cava volume). The curve above Vo began at a lower value than the end of the curve below Vo.