The National Center for Complementary and Integrative Health (NCCIH) is interested in supporting the development of innovative predictive models related to the mechanisms of complementary and integrative approaches, including natural products and mind and body interventions, in human subjects or appropriate model systems.  Randomized clinical trials to validate the predictive models in humans are not supported by this FOA and should seek other funding mechanisms supported by the NCCIH.   Examples of research topics include but are not limited to:

Dear Colleagues,

The NIH Big Data to Knowledge (BD2K) initiative, https://datascience.nih.gov/bd2k) announces the release of an RFA for software and methods development in biomedical big data science: "Big Data to Knowledge (BD2K) Development of Software Tools and Methods for Biomedical Big Data in Targeted Areas of High Need (U01)"  (http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-15-017.html).

This FOA solicits new theories, computational models, and statistical methods to derive understanding of brain function from complex neuroscience data.  Approaches could include the creation of new theories, ideas, and conceptual frameworks to organize/unify data and infer general principles of brain function; new computational models to develop testable hypotheses and design/drive experiments; and new mathematical and statistical methods to support or refute a stated hypothesis about brain function, and/or assist in detecting features in complex brain data.  It is expected that t

Changes in the structural and functional properties of Skeletal muscle have been observed after exposure to a microgravity environment (summarized in the muscle risk evidence report, available at http://humanresearchroadmap.nasa.gov/evidence/reports/Muscle.pdf?rnd=0…).

Some crewmembers on long-duration missions to the International Space Station (ISS) have experienced ophthalmic anatomical changes and visual performance decrements with varying degrees. In these cases, data suggest that intracranial pressure is simultaneously increased. NASA medical operations and research personnel have hypothesized that the microgravity induced cephalad fluid shift may be partially responsible for the observed ophthalmic changes through biomechanical means.