This symposium will focus on modeling of biological systems using single-cells as a natural level of abstraction. Unlike continuum models where cells are represented in the form of density, cell-level modeling provides modelers with deeper insights into biological phenomena and ultimately allows for easy integration with subcellular models. This method is capable of determining single cell phenomena based on more detailed subcellular models than those employed by continuum methods.

Victor Barocas, Multi-Scale Mechanics of Bioengineered Tissues

These symposia explore the interface between macroscale function and microscale physiology with the perspective from the macroscale to the microscale. This theme includes the modulation and control of macroscale whole-organ-level function from its interactions with microscale muscle and neurophysiological processes, and the corresponding diseases associated with disruption between the micro and micro scale dynamics. It also includes systems level function from the integration of multiple microscale components.

These symposia explore the interface between macroscale function and microscale physiology with the perspective from the macroscale to the microscale. This theme includes the modulation and control of macroscale whole-organ-level function from its interactions with microscale muscle and neurophysiological processes, and the corresponding diseases associated with disruption between the micro and micro scale dynamics. It also includes systems level function from the integration of multiple microscale components.

The panel will discuss common issues we share in multiscale imaging and image analysis. Tentative issues to be addressed are as follows.

• Multiscale aspects of imaging and image analysis/modeling
• Multimodality integration
• Data and tool sharing strategies
• Establishing scientific collaboration

Working Group 1: Filament Dynamics and Simulation (FDS) 

Working Group Leads: Victor Barocas, baroc001@umn.edu, Roger Kamm, rdkamm@mit.edu

Goals and Objectives:

Our goal is to develop and implement models of filament-filament and filament-fluid interactions in biological systems so as to increase our understanding of biology and to identify new approach to medical diagnosis and treatment.

• In memory of Marco Cabrera (1954-2009)

Working Group Lead: Dan Beard, dbeard@mcw.edu

Goals and Objectives: The main objective of this working group is to share strategies, databases, and programs to facilitate collaborations leading to the development of integrated multi-scale models of skeletal/cardiac muscle physiology.

Working Group Lead: Yoonsuck Choe (choe@tamu.edu)