Complement-Animal Research In Experimentation (Complement-ARIE)

The National Institutes of Health (NIH) Common Fund is conducting strategic planning for a potential Complement-Animal Research In Experimentation (Complement-ARIE) program concept to catalyze the development, standardization, validation, and use of New Approach Methodologies (NAMs) that will more accurately model human biology.

As part of the NIH’s Complement-ARIE strategic planning working group, the Office of Strategic Coordination (Common Fund) intends to publish a prize competition announcement to solicit entries for new methods and approaches that would complement, make more efficient, or, in some cases, replace traditional animal models, transforming the way biomedical researchers conduct basic, translational, and clinical sciences.

The notice informs potential solvers about the upcoming opportunity to compete in the Complement-ARIE Challenge. The NIH Common Fund plans to award a total prize purse of up to $1,000,000 to as many as 20 winners (up to $50,000 each). To be eligible to win prizes, participants must be led by a Team Leader who is a citizen or permanent resident of the United States or be an entity incorporated in and maintaining a primary place of business in the United States.

Publication of the Challenge announcement and launch of the submission portal are planned for November 7, 2023. The estimated submission deadline is January 11, 2024.

To learn more and to register to follow the challenge please visit:

Potential applicants are encouraged to sign up for the Complement-ARIE listserv to receive updates about the Challenge and other ongoing Complement-ARIE concept planning activities:


Please direct all inquiries to:

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