A model of baroreceptor transduction of blood pressure
Description
A model of baroreceptor transduction of blood pressure consisting of
i.) A linear viscoelastic description of arterial wall strain taken from [1]
ii.) A linear viscoelastic coupling of arterial wall strain to nerve ending
strain from [1]
iii.) A Hodgkin-Huxley type neuron model consisting of voltage gated sodium and
potassium channels with kinetics parameterized by [2], a mechanosensitive
ion channel and a sodium leakage current.
iv.) The action potential peaks are detected and an instantaneous firing rate is
calculated.
Equations
None.
The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
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1. A. Mahdi, J. Sturdy, J. Ottesen, M. Olufsen. _Modeling the afferent dynamics of the baroreflex control system._
PLoS Computational Biology 9(12).
2. Schild JH, Clark JW, Hay M, Mendelowitz D, Andresen MC, et al.
_A- and c-type rat nodose sensory neurons: model interpretations of dynamic discharge characteristics._
J Neurophysiol
Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.