1. Welcome to the NSR Physiome Project!
  2. Physiome JSim
  3. The JSim Documentation Set
  4. JSim Bifurcation Analysis

JSim Bifurcation Analysis

Overview

Bifurcation analysis explores mulitple stationary states, both stable and unstable, within a model. There are several approaches within JSim:

  • Problems with multiple stable stationary states can be explored by writing the analysis directly within the model. Curated NSR Physiome models using this approach can be found by searching for 'bifurcation' in the model search page here.
  • A bifurcation analysis tab for JSim is currently under development. In this tab, the user specify a parameter of interest and a range of exploration. The analysis with link to the AUTO package to generate a bifurcation diagram. The AUTO package allow exploration of both stable and unstable stationary states.
  • Export of JSim models to XPP/XPPAUT is currently under development. Once complete, users may export their models to the XPPAUT system for bifurcation analysis there.

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Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.