Four segment (larynx, trachea, bronchi, alveoli) pressure-flow model represents the respiratory system and it is driven by pleural pressure.
Description
This model represents the airway with four segments: the larynx, trachea, bronchi, and alveoli. The pressure is applied to the compliances, Com2, Com3, Com4, of the three segments that are within the chest cavity.
Figure Legend: p: Pressure, R: Resistance, F: Flow, Com: Compliance, V: Volume
Equations
- Download JSim model MML code (text):
- Download translated SBML version of model (if available):
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Rideout V. C., Mathematical and Computer Modeling of Physiological Systems, Prentice Hall, 1991, p137-143
Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.