Vessel Smooth Muscle Electrophysiology model with stress-controlled Na+ conductance of the NSC channel.
This model is a modification to the VSM electrophysiology model by Kapela et al. that includes a stress-controlled Na+ conductance of the NSC channel which is posited as a possible channel involved with the acute diameter regulation in the myogenic response in the paper by Carlson and Beard. The simulation project file as originally designed here replicates Figure 3 from Kapela et al. with a ramped increase in stress applied to the VSM cell starting at 10000 ms and reaching 100 kPa at 42500 ms followed by a ramped decrease back to 0 kPa at 75000 ms.
The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
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Kapela A, Bezerianos A and Tsoukias NM. A mathematical model of Ca2+ dynamics in rat mesenteric smooth muscle cell: agonist and NO stimulation. Journal of Theoretical Biology 253:238-260, 2008. Carlson BE and Beard DA. Mechanical control of cation channels in the myogenic response. Journal of Physiology (in submission)
Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.