Blood tissue exchange model for heart capillaries uses literature values for constants to fit multiple indicator dilution data from tracer data through perfused dog hearts. Estimates for permeability surface areas for each solute are made.
This model expands on the framework of the BTEX40 model, using the physiologically correct variables for blood tissue exchange through capillaries in the heart. In order to determine permeability-surface areas and extraction values for flows through the organ, multiple indicator dilution data is used from canine hearts. This code also allows comparison of the fitted PSg values to those offered by the traditional Crone equation. The method uses indicator solutes such as labeled albumin, sucrose, glucose, potassium and sodium to demonstrate the uptake and outflow of each solute. The extractions of the latter solutes are determined with respect to albumin, with only vascular behaviors, and these extractions can be used to compare to the calculations of permeability surface area values for across the endothelial cell gap for each of the solutes.
The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
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Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.