Model number


A lumped parameter model of cerebral blood flow control combining cerebral autoregulation and neurovascular coupling


The present model describes cerebral blood flow control including 
neurogenic, myogenic, metabolic, and shear stress based regulation. 
The cerebral vascular bed is modeled using a lumped parameter model, 
describing arterial, arteriolar and venous compartments. Arterial 
and venous compartments are modeled using linear components. The 
arteriolar vessel wall is described by Laplace's law, incorporating 
elastic, muscular and viscous components. The muscular (i.e., smooth
muscle cells in the vessel wall) component's tension is actively 
regulated via the aforementioned regulatory mechanisms. For more 
information, the reader is referred to the paper by Spronck et al.

Model code is currently configured to recreate Figure 7 of the paper 
which represents a NVC overshoot arising from neuronal-myogenic 
interaction. To simulate an eye opening, a function generator has been 
created to change the value of A_neuro from its baseline state of 0 to 
1 at time=1 second. To recreate Figure 8 of the paper (representing a 
NVC overshoot from interaction of neurogenic, myogenic, and metabolic 
regulation), Tau_neuro should be changed from 5 seconds to 10 seconds 
and G_meta should be changed from 0 to -60.





The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

Download JSim model project file


Help running a JSim model.

Spronck B, Martens EGHJ, Gommer ED, van de Vosse FN.
	A lumped parameter model of cerebral blood flow control combining
	cerebral autoregulation and neurovascular coupling
	American Journal of Physiology - Heart and Circulatory Physiology (July 9, 2012). 
	doi: 10.1152/ajpheart.00303.2012
Key terms
cerebral blood flow regulation
physiological model
myogenic regulation
neurogenic regulation
visually evoked flow response

Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.