Model number


(Matlab) Three-Wall Segment (TriSeg) Model Describing Mechanics and Hemodynamics of Ventricular Interaction.


Abstract: mathematical model (TriSeg model) of ventricular mechanics incorporating mechanical interaction of the left and right ventricular free walls and the interventricular septum is presented. Global left and right ventricular pump mechanics were related to representative myofiber mechanics in the three ventricular walls, satisfying the principle of conservation of energy. The walls were mechanically coupled satisfying tensile force equilibrium in the junction. Wall sizes and masses were rendered by adaptation to normalize mechanical myofiber load to physiological standard levels. The TriSeg model was implemented in the previously published lumped closed-loop CircAdapt model of heart and circulation. Simulation results of cardiac mechanics and hemodynamics during normal ventricular loading, acute pulmonary hypertension, and chronic pulmonary hypertension (including load adaptation) agreed with clinical data as obtained in healthy volunteers and pulmonary hypertension patients. In chronic pulmonary hypertension, the model predicted right ventricular free wall hypertrophy, increased systolic pulmonary flow acceleration, and increased right ventricular isovolumic contraction and relaxation times. Furthermore, septal curvature decreased linearly with its transmural pressure difference. In conclusion, the TriSeg model enables realistic simulation of ventricular mechanics including interaction between left and right ventricular pump mechanics, dynamics of septal geometry, and myofiber mechanics in the three ventricular walls.

Running the CircAdapt_TriSeg model

This model is written in Matlab. Please down load the following PDF and zip file which describe the use of the model in Matlab:

If you have any questions or comments regarding this model please email:


JOOST LUMENS, TAMMO DELHAAS, BORUT KIRN,and THEO ARTS: "Three-Wall Segment (TriSeg) Model Describing Mechanics and Hemodynamics of Ventricular Interaction", Annals of Biomedical Engineering, Vol. 37, No. 11, November 2009, pp. 2234-2255

Arts, T., T. Delhaas, P. Bovendeerd, X. Verbeek, and F. W. Prinzen: Adaptation to mechanical load determines shape and properties of heart and circulation: the Circ-Adapt model. Am. J. Physiol. Heart Circ. Physiol.288:H1943-H1954, 2005

Kerckhoffs RCP, Neal ML, Gu Q, Bassingthwaighte JB, Omens JH, and McCulloch AD. Coupling of a 3D finite element model of cardiac ventricular mechanics to lumped systems models of the systemic and pulmonary circulation. Ann Biomed Eng 35: 1-18, 2007.

Neal ML and Bassingthwaighte JB. Subject-specific model estimation of cardiac output and blood volume during hemorrhage. Cardiovasc Eng 7: 97-120, 2007.

Key terms
Pulmonary hypertension
Septal motion
Cardiac mechanics

Please cite in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

Model development and archiving support at provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.