Two solutes, with given total concentrations, Atot and Ftot, bind with an equilibrium dissociation constant of Kd. The result gives the concentrations of A, F, and AF after equilibration. Check affirms totals.
Equilibration calculation used in Barta et al (2000) Barta E, Sideman S, and Bassingthwaighte JB. Facilitated diffusion and membrane permeation of fatty acid in albumin solutions. Ann Biomed Eng 28: 331-345, 2000. COMMENT: Choosing Kd = 330 gives F = AF = 270 with ATot 600 and Ftot 540 uM. Choosing Kd = 240 gives A = AF = 270 with ATot 600 and Ftot 540 uM.
The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
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Barta E, Sideman S, and Bassingthwaighte JB. Facilitated diffusion and membrane permeation of fatty acid in albumin solutions. Ann Biomed Eng 28: 331-345, 2000.
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