Model number
0430

Two solutes, with given total concentrations, Atot and Ftot, bind with an equilibrium dissociation constant of Kd. The result gives the concentrations of A, F, and AF after equilibration. Check affirms totals.

Description

  Equilibration calculation used in Barta et al (2000)
  Barta E, Sideman S, and Bassingthwaighte JB. Facilitated diffusion and
  membrane permeation of fatty acid in  albumin solutions.
  Ann Biomed Eng 28: 331-345, 2000.

  COMMENT: Choosing Kd = 330 gives F = AF = 270 with ATot 600 and Ftot 540 uM.
           Choosing Kd = 240 gives A = AF = 270 with ATot 600 and Ftot 540 uM.

Equations

The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

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References
  Barta E, Sideman S, and Bassingthwaighte JB. Facilitated diffusion and membrane 
  permeation of fatty acid in  albumin solutions. Ann Biomed Eng 28: 331-345, 2000.
	
Key terms
fatty acid binding
Equilibrium dissociation constant
albumin
modeling tools
Acknowledgements

Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.