Model number

Two Region BTEX Model describing serotonin uptake by lung tissue. From Jardine et al. 2013 paper based on model by Linehan et al, 1998.


  2 Region Axially Distributed Blood Tissue Exchange (BTEX) Model applied to analysis of 
  serotonin uptake by lung tissue following injection into pulmonary artery.
  From article:
   - "The Uptake and Metabolism of Substrate...".by Linehan et al
   - In "Whole Organ Approaches to Cellular Metabolism", chp 17
   - Edited by Bassingthwaighte, Goresky, Linehan, 1998

 This two region BTEX model is used to compare and contrast with four region BTEX model 
 in Jardine paper (in press). Data from Rickaby et al., 1981, 1984, and 
 Malcorps et al. 1984.

 Three curve model used to fit physiological variables to three
 sets of data at three different concentrations simulataneously. 
 Each separate curve has aaa, bbb, ccc, suffix 
 on the model variable.
	- Example: CMpaaa(t,x): Conc curve one for mother in plasma.
	- 	   CMpbbb(t,x): Conc curve two
	- 	   CMpccc(t,x): Conc curve three

	- PSev: Passive conductance channel between ISF and Plasma.
	- PSxv: Concentration dependent transporter between Plasma and Extravascular region	
	- Gxv: Extravascular consumption, can be set to zero.
 Multiple Indicator dilution model.
	2 region model that includes serotonin tracer curves.
 Capillary heterogeneity is taken into account. 
	- Based on Audi, "Heterogeneity of Capillary Transit Times", 1998
 Constant infusion:
  - Model can accommadate constant infusion of Mother substrate into system.
    At time t.min the arteriol has a concentration of CMpaaa_init. When a bolus 
    is injected then at x1.min = Cin + CMpaaa_init. Can have three different 
    infusion rates, one for each curve. Assumption: There is no uptake of Mother 
    in Arteriols.
        - Note: if just want system at a const Mother conc then modify the BCs
	  so that:  when (t=t.min) { CMvaa1  = 0; }   becomes:
	  when (t=t.min) { CMvaa1  = CMpaaa_init; }

       Competitve inhibitor on PSxv 
        - Ki is the inhibitor constant (k_i/ki) , where k_i is the off rate of the 
          reaction:     ki
                  E + I <-> EI

Other models in Jardine 2013 paper:


The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

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Key terms
transport modeling
pulmonary capillary permeability
capillary-tissue exchange
hydroxy-tryptamine receptors

Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.