Model number


This model simulates the electophysiological effect of inexcitable cardiac fibroblast when coupled with cardiac myocytes.


 This model simulates the role of cardiac fibroblasts on the action potential of cardiac 
 myocytes when they are coupled together. The modulation of action potential can be 
 explored by varying the number of fibroblasts coupled with a single myocyte and the 
 intercellular resistance between myocytes and fibroblasts. The purpose of this model is 
 to gain insights into the contribution of inexcitable cardiac fibroblasts to the 
 electrophysiology of the myocardium. An electrophysiological fibroblast model developed 
 by Sachse et al. and was coupled with the myocyte model of Pandit et al. The full model 
 was created by Sachse et al. 2008.

fig 1

Figure: To reproduce figure 7, load model in JSim, select the 'Loops Run' from the 'All_Runs' pulldown menu and let the simulation run. To view the graph select the 'Figure_7ab' tab in the right panel of the JSim interaface.


The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

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Help running a JSim model.

 Sachse FB, Moreno A, Abildskov JA.; Electrophysiological modeling of fibroblasts and 
 their interaction with myocytes. Annals of Biomedical Engineering, 36(1): 41-56, 2008

 Pandit SV, Clark RB, Giles WR, Demir SS.
 A mathematical model of action potential heterogeneity in adult left ventricular mycytes.
 Biophysical Journal 81:3029-3051, 2001.
Key terms
Action potential
Action potential duration
Upstroke velocity
Cell Physiology

Please cite in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

Model development and archiving support at provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.