Model number


Noble's 1998 improved guinea-pig ventricular cell model. It incorporates a diadic space, rapid and slow potassium currents and length and tension-dependent processes.


 In their 1998 paper, Denis Noble, Anthony Varghese, Peter Kohl and Penny Noble extended 
 the guinea-pig ventricular cell model (originally developed in 1991 by Noble et al) 
 to include accumulation and depletion of calcium in a diadic space between 
 the sarcolemma and the sarcoplasmic reticulum, where the majority of calcium-induced 
 calcium release is triggered. The model also includes rapid (i_Kr) and slow 
 (i_Ks) components of the delayed rectifier current, and length- and tension-dependent 
 changes in mechanical and electrophysiological processes have been incorporated.

 Drug-receptor interactions have also started to be modeled using the sodium 
 channel as an example. The drugs used have the effect of blocking the inactivation 
 h-gate of the fast sodium channel. (Description copied from the CellML website).

This model was downloaded from the CellML repository then translated by Erik Butterworth (CellML to JSim MML) on 28Nov05. We have added code at the top to define time, t and t. min and t. max in order to run the translation. It is otherwise exactly as derived from CellML website.

fig 1


The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

Download JSim model project file


Help running a JSim model.

 Noble, D., Varghese, A., Kohl, P. & Noble, P: (1998), Improved guinea-pig ventricular cell 
 model incorporating a diadic space, IKr and IKs, and length- and tension-dependent 
 processes, Canadian Journal of Cardiology, 14, 123–134. 	


Key terms
cell physiology
action potential
potassium current
ventricular cell
sarcoplasmic reticulum

Please cite in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

Model development and archiving support at provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.