This is a one compartment lung mechanic model with alveolar O2-CO2 exchange with.
This model simulates an open loop resistor-capacitor network of 3 volumes in series driven by an oscillatory pressure generator (Psource). The convective transport of material in the flow is handled for negative and positive flow (+ve is from Air to V1) by changing the equations by windowing the elements in accord with the direction of flow, the x's. Diffusive (or non-plug flow dispersion) is approximated by an axial dispersion DAx between mixing chambers, where DAx = a diffusion coeff (cm^2/s) times an Area (cm^2) / axial distance (cm). Features: Positive pressure ventilation; Airway with axial dispersion;Alveolar exchange.
The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
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M.G. Levitsky, Pulmonary Physiology, Sixth Edition, McGraw Hill, 2003.
Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.