This model reproduces the action potential recorded experimentally for epicardial myocytes isolated from the adult rat left ventricle (Pandit et al. 2001).
This model simulates action potential of the epicardial myocytes from the rat left ventricle. The model can be modified to also represent the action potential of the endocardial left ventricular myocytes of the rat as outlined below in the equations section and in the paper by Pandit et al. referred to below. The two versions were used in to support the hypothesis that smaller number and altered kinetics of the transient outward K+ channel can account for the longer action potential duration seen in endocardial myocytes. The longer action potential duration other novel emergent behavior such as enhanced amplitude of the sustained K+ current and a larger influx of Ca2+.
(From Pandit et al. 2001):
The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
We welcome comments and feedback for this model. Please use the button below to send comments:
- Pandit SV, Clark RB, Giles WR, Demir SS.; A mathematical model of action potential heterogeneity in adult left ventricular mycytes. Biophysical Journal 81:3029-3051, 2001.
- Sachse FB, Moreno A, Abildskov JA.; Electrophysiological modeling of fibroblasts and their interaction with myocytes. Annals of Biomedical Engineering, 36(1): 41-56, 2008
Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.