(Matlab) Integrated compartmental model of amino acid transport in the placenta. Model describes amino acid interactions between three placental compartments, which are regulated by three transport mechanisms.
The model describes the complex interactions of four amino acid groups in three compartments (maternal, syncytiotrophoblast, and fetal). The amino acids are regulated between these compartments via transport proteins, which have three different mechanisms (accumulative, exchange, and facilitated transport). The compartmental model incorporates initial amino acid levels in each compartment, and blood flow inputs in the maternal and fetal compartments.
The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
We welcome comments and feedback for this model. Please use the button below to send comments:
- (Primary) Panitchob, N., Widdows, K.L., Crocker, I.P., Johnstone, E.D., Please, C.P., Sibley, C.P., Glazier, J.D., Lewis, R.M. & Sengers, B.G. 2016, Computational modelling of placental amino acid transfer as an integrated system, BBA-Biomembranes, (doi:10.1016/j.bbamem.2016.03.028).
- Souba, W.W. & Pacitti, A.J. 1992, Review: How Amino Acids Get Into Cells: Mechanisms, Models, Menus, and Mediators. Journal of Parenteral and Enteral Nutrition 16, 569-578. (doi:10.1177/0148607192016006569).
- Pradhan, R.K., Vinnakota, K.C., Beard, D.A. & Dash, R.K. 2013, Chapter 5 - Carrier-Mediated Transport Through Biomembranes. In Transport in Biological Media (eds. S.M. Becker & A.V. Kuznetsov), pp. 181-212. Boston, Elsevier.
- Sengers, B.G., Please, C.P. & Lewis, R.M. 2010 Computational modelling of amino acid transfer interactions in the placenta. Experimental physiology 95, 829-840. (doi:10.1113/expphysiol.2010.052902).
- Mayhew, T.M. 2009 A stereological perspective on placental morphology in normal and complicated pregnancies. Journal of Anatomy 215, 77-90. (doi:10.1111/j.1469-7580.2008.00994.x).
Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.