Dose dependency of therapeutic monoclonal antibody (mAb), 2F8, binding to epidermal growth factor receptor (EGFR).
This is a model for the dose dependency of a therapeutic monoclonal antibody (mAb), 2F8, binding to epidermal growth factor receptor (EGFR). There are three sets of data (low dose, designated with suffix 2, high dose, designated with suffix 20, and a higher dose, designated with suffix 40). The structure of this model is to have three duplicate models with shared parameters for simultaneous optimization of the three corresponding data sets.
The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
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J.J. Lammeerts van Bueren, W.K. Bleeker, H.O. Bogh, M. Houtkamp, J. Schuurman, J.G.J. van de Winkel, and W.H.I. Parren. Effect of Target Dynamics on Pharmacokinetics of a Novel Therapeutic Antibody against the Epidermal Growth Factor Receptor: Implications for the Mechanisms of Action. Cancer Res 2006 (15): August 1, 2006. p 7630-7638.
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The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.