A model for a physiological based description of the inhalation pharmacokinetics of styrene in rats and humans based on the work of J.C. Ramsey and M.E. Andersen [(1984). Toxicol Appl Pharm. 73(1), 159-175.], developed by Neil Geisler (2006) as a final project for BIOEN 589, University of Washington.
This model presents a the phramacokinetics of styrene inhalation in rats and humans based on the 1984 paper by Ramsey and Andersen paper (reference below). Four body compartments are considered: richly perfused tissue (highly perfused), muscle (moderately perfused), fat (slowly perfused), and liver, which includes metabolic consumption of styrene. Styrene is inhaled at a given concentration for a specified time, then normal ventilation continues. Parameters for rats and humans are included, and are listed in the code below along with parameters for mice as provided in the paper. Two plot pages, one for rats and one for humans, are given to reflect identical traces plotted in the paper.
Styrene uptake, release, and metabolism in the tissue:
The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
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Andersen, J.C. and Ramsey, M.E., A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans, 1984 Toxicol Appl Pharmacol, 73(1), 159-175.
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The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.