Models a two compartment, 2 solute, T1-T2 (facilitated 6-state transporter with effective PS calculation. Directly related to model Transp2sol.Comp2 (model #10).

Description

   Transp2sol.Comp2.PS is a six state transporter model for 2 solutes in 
 which compete for the transporter site on both sides of a membrane
 between two instantaneously mixed compartments. In comparmtment 2, A 
 is reacted to form B in an enzymatic reaction approximated by a 
 Michaelis-Menten expression without any accounting for binding of 
 solutes to the enzyme. When the rates of conformational state change 
 for transmembrane flipping of TA and TB are high compared to that for uncomplexed 
 transporter T, or if Kds for the transporter binding are low compared to the 
 substrate concentrations, then the model behaves much like an obligatory 
 countertransporter, exchanging B for A across the membrane. 

   This secondary model (See Transp2.sol.Comp2 for more detail) has a 
 Michaelis-Menten PS term (MMA1, MMA2) which is valid when assuming the 
 transporter (T) has high on- and off rates and transmembrane flipping is 
 considered instantaneous. Use the MMA2 parameter for comparison to A2. 
  

Equations

The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.