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Cardio-ventilatory coupling: sensory input in synchronizing inspiratory-onset activity.

What is being modeled?
A reciprocal relationship between a fast and a slow oscillations
Description & purpose of resource

The respiratory control system produces the rhythm that underlies breathing. But this rhythm is not restricted to just the respiratory system. Teleologically, it is not surprising that the respiratory rhythm  is evident in the cardiovascular system because the sympatho-cardio-respiratory systems are coupled for efficient gas exchange. But the respiratory rhythm permeates non-related systems, as it is evident hippocampal, olfactory and prefrontal cortical rhythms. Further, the respiratory rhythm appears to be sensitive to other rhythms, in particular to that of the pulse pressure. Thus, our overall goal is to dissect mechanisms underlying the variability of this fundamental rhythm.

We and others postulate that the variability of these rhythms may serve as a biomarker of health and disease progression. Thus the purpose of the model is to examine an potential source of variability of cardio-respiratory rhythms.

Spatial scales
whole organism
Temporal scales
10-3 - 1 s
1 - 103 s
This resource is currently
under early-stage development
Has this resource been validated?
Can this resource be associated with other resources? (e.g.: modular models, linked tools and platforms)
Key publications (e.g. describing or using resource)

We are in the final stage of preparing the manuscript describing this model. It is entitled; 
Cardio-ventilatory coupling: a role for carotid baroreflex in synchronizing inspiratory-onset activity. 

Our published preliminary study is 

Hsieh YH, Litvin DG, Zaylor AR, Nethery DE, Dick TE, Jacono FJ.

Brainstem inflammation modulates the ventilatory pattern and its variability after acute lung injury in rodents.

J Physiol. 2020 Jul;598(13):2791-2811.

Thomas E Dick
PI contact information
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