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Hippocampal Large-Scale Model

What is being modeled?
Rat Hippocampus
Description & purpose of resource

The project is to develop a full-scale model of rat hippocampus using compartmental models of individual neurons. The code available can be used to construct the connectivity for an entorhinal-dentate network with lateral and medial entorhinal cortical cells as spike generators and compartmental models of dentate granule cells and basket cells. The code can then be used to run simulations using the network.

Spatial scales
Temporal scales
10-6 - 10-3 s
10-3 - 1 s
1 - 103 s
This resource is currently
a demonstration or a framework to be built upon (perhaps with a sample implementation)
Has this resource been validated?
Key publications (e.g. describing or using resource)
  1. Yu, G.J., Bouteiller, J.-M.C., Song, D., and Berger, T.W.  Axonal anatomy optimizes spatial encoding in the rat entorhinal-dentate system: A computational studyIEEE Transactions on Biomedical Engineering, 2019, 1-1, DOI: 10.1109/TBME.2019.2894410.
  2. Bingham, C.S., Loizos, K., Yu, G.J., Gilbert, A., Bouteiller, J.-M.C., Song, D., Lazzi, G., and Berger, T.W.  Model-based analysis of electrode placement and pulse amplitude for hippocampal stimulation.  IEEE Transactions on Biomedical Engineering, 2018, 99, 1-1, DOI: 10.1109/TBME.2018.2791860.
  3. Hendrickson, P.J., Yu, G.J., Song, D., and Berger, T. W. A million­plus neuron model of the hippocampal dentate gyrus: Critical role for topography in determining spatiotemporal network dynamics. IEEE Transactions on Biomedical Engineering, 2015, 63(1), DOI: 10.1109/TBME.2015.2445771.
Theodore W. Berger
PI contact information
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