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OpenSim: easy-to-use, extensible software for modeling, simulating, controlling, and analyzing the musculoskeletal system

What is being modeled?
The musculoskeletal system of humans and animals.
Description & purpose of resource

OpenSim is a software platform for modeling humans, animals, robots, and the environment, and simulating their interaction and movement. OpenSim has a graphical user interface (GUI) for visualizing models and generating and analyzing simulations. The open source and extensible software also includes an application programming interface (API) that developers can use to extend the software.

More information is available at

Spatial scales
whole organism
Temporal scales
10-3 - 1 s
1 - 103 s
This resource is currently
mature and useful in ongoing research
Has this resource been validated?
How has the resource been validated?

To ensure our models and simulations are biologically accurate, we validate our simulation results by comparing with experimental measures and other independent models and simulations. We also use continuous integration to run a suite of verification tests for the software. For details see Seth et al., 2018.

Can this resource be associated with other resources? (e.g.: modular models, linked tools and platforms)
Which resources?

OpenSim has been linked to other modeling tools such as NMS Builder and finite element modeling software.

Key publications (e.g. describing or using resource)

Seth A, Hicks JL, Uchida TK, Habib A, Dembia CL, Dunne JJ, et al. (2018) OpenSim: Simulating musculoskeletal dynamics and neuromuscular control to study human and animal movement. PLoS Comput Biol 14(7): e1006223. (2018)

Delp SL, Anderson FC, Arnold AS, Loan P, Habib A, John CT, Guendelman E, Thelen DG. OpenSim: Open-source Software to Create and Analyze Dynamic Simulations of Movement. IEEE Transactions on Biomedical Engineering. (2007)

Scott Delp
PI contact information
P2C, R24, U54
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