Contributors
Robert Hester, University of Mississippi Medical Center. Title: Multiscale modeling of Human Physiology.
Institution/ Affiliation
Robert Hester, University of Mississippi Medical Center.
Presentation Details (date, conference, etc.)
January 13, 2022, IMAG/MSM WG on Multiscale Modeling and Viral Pandemics
- Robert Hester, University of Mississippi Medical Center. Title: Multiscale modeling of Human Physiology. Abstract: HumMod is a model of human physiology comprising over 9000 dependent variables, and over 1500 independent parameters. It spans all major body systems, including circulatory, renal, respiratory, hepatic, gastrointestinal, neural, endocrine and muscular systems. Each system is built on one or more working hypotheses/models developed in the literature with reasonable support. These systems combine multiple tissues and their responses to hormones, metabolites, and physical forces. In the laboratory, such responses are considered under controlled circumstances. In the model, the simple mechanisms are tied together to produce feedback loops approximating the body’s own responses to physiological challenges. Current projects include: 1) simulations to understand how medical devices work and 2) simulating virtual populations for in silico clinical trials. YouTube and Slides.