Contributors
Clare Bryant, Professor of Innate Immunity, The University of Cambridge. Title: Conservation of host cell death in response to bacterial infection: carnivores and other species.
Reinhard Laubenbacher, University of Florida. Title: New focus, New subgroup.
Reinhard Laubenbacher, University of Florida. Title: New focus, New subgroup.
Institution/ Affiliation
Clare Bryant, Professor of Innate Immunity, The University of Cambridge.
Reinhard Laubenbacher, University of Florida.
Reinhard Laubenbacher, University of Florida.
Presentation Details (date, conference, etc.)
December 2, 2021, IMAG/MSM WG on Multiscale Modeling and Viral Pandemics
- Clare Bryant, Professor of Innate Immunity, The University of Cambridge. Title: Conservation of host cell death in response to bacterial infection: carnivores and other species. Abstract: Some bacterial species readily induce host cell death upon infection. Salmonella is an efficient cell killer that primarily drives inflammasome cleavage of gasdermin D to induce membrane pores and hence kill macrophages. Cell death is critical to control Salmonella infection in vivo (a) and macrophages from many species die in response to infection with this bacterium yet many of the genes central to inflammasome cell death are either altered or absent across different animals (b). This is surprising for what should be critical signaling pathways for host defense and this talk will cover our work in this area and our approaches to these evolutionary differences. YouTube and Slides.
a. Doerflinger, M., et al. (2020) Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection. Immunity doi.org/10.1016/j.immuni.2020.07.004
b. Digby, Z., et al. (2021) Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections. Cell Reports 36, 109614. Doi:10.1016/j.celrep.2021.109614s.
Additional citations on the inflammasome, and on caspase evolution and species distribution:
1. "Identification of Novel Mammalian Caspases Reveals an Important Role of Gene Loss in Shaping the Human Caspase Repertoire" https://academic.oup.com/mbe/article/25/5/831/1195498
2. "Cytosolic Recognition of Microbes and Pathogens: Inflammasomes in Action" https://journals.asm.org/doi/full/10.1128/MMBR.00015-18
3. "Diet modulates the relationship between immune gene expression and functional immune responses" https://www.sciencedirect.com/science/article/pii/S0965174818304909 - Reinhard Laubenbacher, University of Florida. Title: New focus, New subgroup. YouTube and Slides.