Alex Hoffmann, University of California at Los Angeles. Title:Modeling innate immune signaling: some emerging regulatory principles.
Alex Hoffmann, University of California at Los Angeles.
Presentation Details (date, conference, etc.)
March 3, 2022, IMAG/MSM WG on Multiscale Modeling and Viral Pandemics
- Alexander Hoffmann, UCLA, Modeling innate immune signaling: some emerging regulatory principles: Immune cells must respond appropriately to diverse pathogens or immune stimuli. Four signaling pathways function combinatorially and dynamically to transmit information about the immune threat to nuclear immune response genes. We have developed mathematical models of the molecular networks that recapitulate their stimulus-specific signaling dynamics of the transcription factors NFκB and ISGF3. A number of circuit motifs and regulatory principles give rise to hallmark dynamic features. Their target genes decode these dynamics via molecular mechanisms that may also be accounted by mathematical models. YouTube and Slides.