A Multi-scale Approach to Designing Therapeutics for Tuberculosis

Submitted by kirschne on Wed, 01/15/2020 - 22:46
Authors
Jennifer J. Linderman, Nicholas A. Cilfone, Elsje Pienaar, Chang Gong, Denise E. Kirschner
DOI
10.1039/C4IB00295D
Publication journal
Integrative Biology

Approximately one third of the world's population is infected with Mycobacterium tuberculosis. Limited information about how the immune system fights M. tuberculosis and what constitutes protection from the bacteria impact our ability to develop effective therapies for tuberculosis. We present an in vivo systems biology approach that integrates data from multiple model systems and over multiple length and time scales into a comprehensive multi-scale and multi-compartment view of the in vivo immune response to M. tuberculosis. We describe computational models that can be used to study (a) immunomodulation with the cytokines tumor necrosis factor and interleukin 10, (b) oral and inhaled antibiotics, and (c) the effect of vaccination.

Publication Date
Keywords
tuberculosis