Why is it so difficult to lose weight and keep it off? Our recent study of the “Biggest Loser” contestants demonstrated powerful biological responses that resist weight loss by increasing appetite and slowing metabolism. This presentation will discuss experimental and mathematical modeling studies that quantify the relative magnitude of the biological responses to weight loss and their role in the feedback control of human body weight. Furthermore, I will describe the generally unimpressive long-term results of weight loss diet trials, their implications for treatment of obesity, and why there may not be any “best diet” for weight loss.
Speaker:
Dr. Kevin Hall
Senior Investigator
Chief, Integrative Physiology Section
Laboratory of biological modeling, NIDDK, NIH
Previous at Entelos, Dr. Hall was involved in the development of the Type 1 Diabetes PhysioLab platform, a large-scale mathematical model of diabetes pathogenesis and intervention in the NOD mouse. It was the first in silico animal model for T1D.
At DK, his laboratory investigates “how metabolism and the brain adapt in response to a variety of interventions to diet and physical activity, … perform experiments in both humans and rodents to better understand the complex mechanisms regulating macronutrient metabolism, body composition, and energy expenditure”.
He is heavily involved in clinical studies of body weight regulation. See following links related his research, or NIH programs he initiated
Integrative physiology of metabolism and body weight regulation
More about Dr. Hall’s research at https://www.niddk.nih.gov/about-niddk/staffdirectory/intramural/kevin-ha...
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