Hypertrophic scarring is a major clinical problem characterized by excessive fibrosis that can result in disfigurement, distress, discomfort/pain, and permanent loss of function. In several treatment strategies reduced fibrosis and scarring appears connected to a reduction in force at the wound site. However, the underlying mechanisms that link mechanical environment to fibrosis remain unclear. In addition to the levels of tension at the wound site, multiscale mechanical interactions could also be important and ultimately deterministic of the fibrogenesis that controls scar phenotype in a healed surgical wound. These interactions develop from the interplay between the geometry, structure, and organization of the clot, the internal forces generated by the constituent cells (fibroblasts and macrophages), and external boundary constraints of the wound. In this webinar, Dr. Sander will discuss the development of a new model system for studying the mechanobiological basis of scar formation by combining experiments with multiscale mechanical computational models.
Webinar Start Date
Dr. Edward Sander