2009 IMAG Futures Report - Challenges

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Multiscale Modeling U01Projects

2009 IMAG Futures Report Challenges/PAR-15-085 bullets

1)    Next-generation multiscale models that integrate between different scientific fields (e.g. cardiovascular and neuroscience) and predict integrated functions

·         BEARD, DANIEL A (contact); KASSAB, GHASSAN S - Coronary Blood Flow: Integrated Theory and Experiments

·         BLEMKER, SILVIA SALINAS (contact); PEIRCE-COTTLER, SHAYN  - Multiscale Modeling for Treatment Discovery in Duchenne Muscular Dystrophy

·         BLUESTEIN, DANNY  - Multiscale Modeling of Blood Flow and Platelet Mediated Thrombosis

·         CARLSON, ROSS P (contact); FIELDS, MATTHEW W; HANLEY, LUKE ; HENSON, MICHAEL  - Predictive Multiscale Modeling of Microbial Consortia Biofilms

·         DHAHER, YASIN YOUSEF (contact); THELEN, DARRYL G - A Multi-Scale Modeling Construct of Knee Mechanics following ACL Reconstruction

·         DIAMOND, SCOTT L - Multiscale Analysis of Trauma

·         GLAZIER, JAMES ALEXANDER (contact); DUNN, KENNETH W; KLAUNIG, JAMES E - Development of a Multiscale Mechanistic Simulation of Acetaminophen Induced Liver

·         HAUGH, JASON M - Multiscale Modeling of Wound Healing

·         KAPLAN, DAVID L (contact); BUEHLER, MARKUS J - Models to Predict Protein Biomaterial Performance

·         KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy

·         LAZZI, GIANLUCA  (contact); BERGER, THEODORE W - Predictive modeling of bioelectric activity on mammalian multilayered neuronal st

·         LEDERER, W JONATHAN (contact); JAFRI, MOHSIN SALEET; MANNELLA, CARMEN A - Multiscale spatiotemporal modeling of cardiac mitochondria

·         LYTTON, WILLIAM W - Microconnectomics of neocortex: a multiscale computer model

·         SANGER, TERENCE D (contact); GISZTER, SIMON F - Multiscale models of neural population control in spinal cord

·         SCHWABER, JAMES  (contact); VADIGEPALLI, RAJANIKANTH  - Multiscale Model of the Vagal Outflow to the Heart

·         SECOMB, TIMOTHY W - Multiscale modeling of cerebral blood flow and oxygen transport

·         YANKEELOV, THOMAS E (contact); QUARANTA, VITO  - Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer

·         ZAMAN, MUHAMMAD HAMID (contact); GERTLER, FRANK B; KAMM, ROGER D; LAUFFENBURGER, DOUGLAS A - Modeling bi-directional signaling and cytoskeletal dynamics in 3D cell migrations

·         ZAWIEJA, DAVID CARL (contact); MOORE, JAMES E - Transport Phenomena in the Lymphatic System

          ·         BORON, WALTER F. (contact); TAJKHORSHID, EMAD; SOMERSALO, ERKKI - Multi-scale modeling of gas transport through channels in living cells

2)    Higher level models and modeling approaches that integrate multiple physiological (and possibly psychological) systems in order to better understand the human response (e.g. to extended space flight, and other unique environments)

·         BLEMKER, SILVIA SALINAS (contact); PEIRCE-COTTLER, SHAYN  - Multiscale Modeling for Treatment Discovery in Duchenne Muscular Dystrophy

·        DICK, THOMAS E - Modeling Brainstem Inflammations Role in Systemic Dysfunction during Sepsis

·         FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension

3)    Novel methods to fuse data-rich and data-poor scales to enable predictive modeling

·         BASANTA GUTIERREZ, DAVID  (contact); LYNCH, CONOR C - Multiscale Modeling of Bone Environment Responses to Metastatic Prostate Cancer

·         BLEMKER, SILVIA SALINAS (contact); PEIRCE-COTTLER, SHAYN  - Multiscale Modeling for Treatment Discovery in Duchenne Muscular Dystrophy

·         CANNON, WILLIAM R (contact); DUNLAP, JAY C - Multiscale Modeling of Circadian Rhythms

·         CARLSON, ROSS P (contact); FIELDS, MATTHEW W; HANLEY, LUKE ; HENSON, MICHAEL  - Predictive Multiscale Modeling of Microbial Consortia Biofilms

·         FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension

·         GLAZIER, JAMES ALEXANDER (contact); DUNN, KENNETH W; KLAUNIG, JAMES E - Development of a Multiscale Mechanistic Simulation of Acetaminophen Induced Liver

·         HAUGH, JASON M - Multiscale Modeling of Wound Healing

·         HENSON, MICHAEL  (contact); HERZOG, ERIK ; KEVREKIDIS, YANNIS G - Multiscale Modeling of the Mammalian Circadian Clock: The Role of GABA Signaling

·         KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy

·         LEDERER, W JONATHAN (contact); JAFRI, MOHSIN SALEET; MANNELLA, CARMEN A - Multiscale spatiotemporal modeling of cardiac mitochondria

·         LIN, CHING-LONG  - An integrative statistics-guided image-based multi-scale lung model

·         LYTTON, WILLIAM W - Microconnectomics of neocortex: a multiscale computer model

·         SANGER, TERENCE D (contact); GISZTER, SIMON F - Multiscale models of neural population control in spinal cord

·         SAUNDERS, MICHAEL ALAN - Multiscale Molecular Systems Biology: Reconstruction and Model Optimization

·         ZAWIEJA, DAVID CARL (contact); MOORE, JAMES E - Transport Phenomena in the Lymphatic System

·         BORON, WALTER F. (contact); TAJKHORSHID, EMAD; SOMERSALO, ERKKI - Multi-scale modeling of gas transport through channels in living cells

4)    Novel methods to fuse biological and/or behavioral processes and mechanisms to model outcomes as a result of various interventions

·         ALBER, MARK  - Multiscale modeling and empirical study of a mechanism limiting blood clot growth

·         BLEMKER, SILVIA SALINAS (contact); PEIRCE-COTTLER, SHAYN  - Multiscale Modeling for Treatment Discovery in Duchenne Muscular Dystrophy

·         BLUESTEIN, DANNY  - Multiscale Modeling of Blood Flow and Platelet Mediated Thrombosis

·         CAMPBELL, KENNETH S (contact); WENK, JONATHAN F - Multiscale modeling of inherited cardiomyopathies and therapeutic interventions

·         CARLSON, ROSS P (contact); FIELDS, MATTHEW W; HANLEY, LUKE ; HENSON, MICHAEL  - Predictive Multiscale Modeling of Microbial Consortia Biofilms

·         DHAHER, YASIN YOUSEF (contact); THELEN, DARRYL G - A Multi-Scale Modeling Construct of Knee Mechanics following ACL Reconstruction

·        DICK, THOMAS E - Modeling Brainstem Inflammations Role in Systemic Dysfunction during Sepsis

·         FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension

·         HOLMES, JEFFREY W - Multiscale Models of Cardiac Growth, Remodeling, and Myocardial Infarction

·         LAZZI, GIANLUCA  (contact); BERGER, THEODORE W - Predictive modeling of bioelectric activity on mammalian multilayered neuronal st

·         LIN, CHING-LONG  - An integrative statistics-guided image-based multi-scale lung model

·         LYTTON, WILLIAM W - Microconnectomics of neocortex: a multiscale computer model

·         SANGER, TERENCE D (contact); GISZTER, SIMON F - Multiscale models of neural population control in spinal cord

·         YANKEELOV, THOMAS E (contact); QUARANTA, VITO  - Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer

5)    Reproducible and reusable multiscale models that will be integrated and adopted into model-poor fields (e.g.  tissue engineering, regenerative medicine, drug and gene delivery, preventive interventions)

·         ALBER, MARK  - Multiscale modeling and empirical study of a mechanism limiting blood clot growth

·         BASSINGTHWAIGHTE, JAMES B (contact); BEARD, DANIEL A; DASH, RANJAN K; MCCULLOCH, ANDREW D - Analyzing the Cardiac Power Grid: Adaptive responses to fluctuating local demand

·         CANNON, WILLIAM R (contact); DUNLAP, JAY C - Multiscale Modeling of Circadian Rhythms

·         ECKMANN, DAVID M (contact); RADHAKRISHNAN, RAVI  - Bridging multiple scales in modeling targeted drug nanocarrier delivery

·         GENIN, GUY M (contact); THOMOPOULOS, STAVROS  - Cross-scale interactions between mineral and collagen for tendon-bone attachment

·         GLAZIER, JAMES ALEXANDER (contact); DUNN, KENNETH W; KLAUNIG, JAMES E - Development of a Multiscale Mechanistic Simulation of Acetaminophen Induced Liver

·         HAUGH, JASON M - Multiscale Modeling of Wound Healing

·         KAPLAN, DAVID L (contact); BUEHLER, MARKUS J - Models to Predict Protein Biomaterial Performance

·         KARNIADAKIS, GEORGE  (contact); DAO, MING ; HIGGINS, JOHN MATTHEW; VEKILOV, PETER G - Multiscale Modeling of Sickle Cell Anemia: Methods and Validation

·         KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy

·         LAUBENBACHER, REINHARD  (contact); MEHRAD, BORNA ; SCHROEDER, WILLIAM J - Modular design of multiscale models, with an application to the innate immune response to fungal respiratory pathogens.

·         LYTTON, WILLIAM W - Microconnectomics of neocortex: a multiscale computer model

·         SAUNDERS, MICHAEL ALAN - Multiscale Molecular Systems Biology: Reconstruction and Model Optimization

·         VADIGEPALLI, RAJANIKANTH  (contact); HOEK, JOANNES B - Modeling Multiscale Control of Liver Regeneration

·         ZAWIEJA, DAVID CARL (contact); MOORE, JAMES E - Transport Phenomena in the Lymphatic System

·         ZHOU, XIAOBO  (contact); YANG, YUNZHI  - Systems Modeling Guided Bone regeneration

6)    Multiscale models strongly coupled with standardized protocols for model-driven data collection

·        BAROCAS, VICTOR H (contact); WINKELSTEIN, BETH A - Multiscale Modeling of Facet Capsule Mechanobiology

·         BASSINGTHWAIGHTE, JAMES B (contact); BEARD, DANIEL A; DASH, RANJAN K; MCCULLOCH, ANDREW D - Analyzing the Cardiac Power Grid: Adaptive responses to fluctuating local demand

·         CANNON, WILLIAM R (contact); DUNLAP, JAY C - Multiscale Modeling of Circadian Rhythms

·         FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension

·         KAPLAN, DAVID L (contact); BUEHLER, MARKUS J - Models to Predict Protein Biomaterial Performance

·         KARNIADAKIS, GEORGE  (contact); DAO, MING ; HIGGINS, JOHN MATTHEW; VEKILOV, PETER G - Multiscale Modeling of Sickle Cell Anemia: Methods and Validation

·         KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy

·         LEDERER, W JONATHAN (contact); JAFRI, MOHSIN SALEET; MANNELLA, CARMEN A - Multiscale spatiotemporal modeling of cardiac mitochondria

·         LYTTON, WILLIAM W - Microconnectomics of neocortex: a multiscale computer model

·         SAUNDERS, MICHAEL ALAN - Multiscale Molecular Systems Biology: Reconstruction and Model Optimization

·         SECOMB, TIMOTHY W - Multiscale modeling of cerebral blood flow and oxygen transport

·         SOBIE, ERIC A (contact); CHRISTINI, DAVID J - Multiscale modeling to map cardiac electrophysiology between species

·         YANKEELOV, THOMAS E (contact); QUARANTA, VITO  - Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer

·         ZAWIEJA, DAVID CARL (contact); MOORE, JAMES E - Transport Phenomena in the Lymphatic System

·         BORON, WALTER F. (contact); TAJKHORSHID, EMAD; SOMERSALO, ERKKI - Multi-scale modeling of gas transport through channels in living cells

7)    Implementing virtual clinical trials with multiscale models to predict outcomes

·         CLANCY, COLLEEN E - Predictive multiscale in silico cardio-pharmacology

·         GLAZIER, JAMES ALEXANDER (contact); DUNN, KENNETH W; KLAUNIG, JAMES E - Development of a Multiscale Mechanistic Simulation of Acetaminophen Induced Liver

·         KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy

·         YANKEELOV, THOMAS E (contact); QUARANTA, VITO  - Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer

8)    Problem-driven multiscale models that require high performance computing

·         ALBER, MARK  - Multiscale modeling and empirical study of a mechanism limiting blood clot growth

·         BASANTA GUTIERREZ, DAVID  (contact); LYNCH, CONOR C - Multiscale Modeling of Bone Environment Responses to Metastatic Prostate Cancer

·         BLUESTEIN, DANNY  - Multiscale Modeling of Blood Flow and Platelet Mediated Thrombosis

·        BAROCAS, VICTOR H (contact); WINKELSTEIN, BETH A - Multiscale Modeling of Facet Capsule Mechanobiology

·         CLANCY, COLLEEN E - Predictive multiscale in silico cardio-pharmacology

·         DHAHER, YASIN YOUSEF (contact); THELEN, DARRYL G - A Multi-Scale Modeling Construct of Knee Mechanics following ACL Reconstruction

·         FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension

·         GUCCIONE, JULIUS MATTEO (contact); KASSAB, GHASSAN S; KUHL, ELLEN  - Multi-Scale Laws of Myocardial Growth and Remodeling

·         HAUGH, JASON M - Multiscale Modeling of Wound Healing

·         KARNIADAKIS, GEORGE  (contact); DAO, MING ; HIGGINS, JOHN MATTHEW; VEKILOV, PETER G - Multiscale Modeling of Sickle Cell Anemia: Methods and Validation

·         KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy

·         LAZZI, GIANLUCA  (contact); BERGER, THEODORE W - Predictive modeling of bioelectric activity on mammalian multilayered neuronal st

·         LIN, CHING-LONG  - An integrative statistics-guided image-based multi-scale lung model

·         LYTTON, WILLIAM W - Microconnectomics of neocortex: a multiscale computer model

·         SECOMB, TIMOTHY W - Multiscale modeling of cerebral blood flow and oxygen transport

·         ZAWIEJA, DAVID CARL (contact); MOORE, JAMES E - Transport Phenomena in the Lymphatic System

·         BORON, WALTER F. (contact); TAJKHORSHID, EMAD; SOMERSALO, ERKKI - Multi-scale modeling of gas transport through channels in living cells

9)    Model predictions that drive a community of experimentalists towards systematic testing and validation

·         ALBER, MARK  - Multiscale modeling and empirical study of a mechanism limiting blood clot growth

·         BASANTA GUTIERREZ, DAVID  (contact); LYNCH, CONOR C - Multiscale Modeling of Bone Environment Responses to Metastatic Prostate Cancer

·         BASSINGTHWAIGHTE, JAMES B (contact); BEARD, DANIEL A; DASH, RANJAN K; MCCULLOCH, ANDREW D - Analyzing the Cardiac Power Grid: Adaptive responses to fluctuating local demand

·         BEARD, DANIEL A (contact); KASSAB, GHASSAN S - Coronary Blood Flow: Integrated Theory and Experiments

·         BLUESTEIN, DANNY  - Multiscale Modeling of Blood Flow and Platelet Mediated Thrombosis

·         CANNON, WILLIAM R (contact); DUNLAP, JAY C - Multiscale Modeling of Circadian Rhythms

·         DIAMOND, SCOTT L - Multiscale Analysis of Trauma

·        DICK, THOMAS E - Modeling Brainstem Inflammations Role in Systemic Dysfunction during Sepsis

·         GENIN, GUY M (contact); THOMOPOULOS, STAVROS  - Cross-scale interactions between mineral and collagen for tendon-bone attachment

·         HAUGH, JASON M - Multiscale Modeling of Wound Healing

·         JARON, DOV  - Multiscale, Transport-Dependent NO Signaling: Cells to Vascular Networks

·         KAPLAN, DAVID L (contact); BUEHLER, MARKUS J - Models to Predict Protein Biomaterial Performance

·         KARNIADAKIS, GEORGE  (contact); DAO, MING ; HIGGINS, JOHN MATTHEW; VEKILOV, PETER G - Multiscale Modeling of Sickle Cell Anemia: Methods and Validation

·         KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy

·         LAZZI, GIANLUCA  (contact); BERGER, THEODORE W - Predictive modeling of bioelectric activity on mammalian multilayered neuronal st

·         LEDERER, W JONATHAN (contact); JAFRI, MOHSIN SALEET; MANNELLA, CARMEN A - Multiscale spatiotemporal modeling of cardiac mitochondria

·         LIN, CHING-LONG  - An integrative statistics-guided image-based multi-scale lung model

·         SECOMB, TIMOTHY W - Multiscale modeling of cerebral blood flow and oxygen transport

·         SOBIE, ERIC A (contact); CHRISTINI, DAVID J - Multiscale modeling to map cardiac electrophysiology between species

·         ZAMAN, MUHAMMAD HAMID (contact); GERTLER, FRANK B; KAMM, ROGER D; LAUFFENBURGER, DOUGLAS A - Modeling bi-directional signaling and cytoskeletal dynamics in 3D cell migrations

·         ZAWIEJA, DAVID CARL (contact); MOORE, JAMES E - Transport Phenomena in the Lymphatic System

·         BORON, WALTER F. (contact); TAJKHORSHID, EMAD; SOMERSALO, ERKKI - Multi-scale modeling of gas transport through channels in living cells

10)  Predictive multiscale models that strongly incorporate uncertainty quantification

·         BASSINGTHWAIGHTE, JAMES B (contact); BEARD, DANIEL A; DASH, RANJAN K; MCCULLOCH, ANDREW D - Analyzing the Cardiac Power Grid: Adaptive responses to fluctuating local demand

·         CANNON, WILLIAM R (contact); DUNLAP, JAY C - Multiscale Modeling of Circadian Rhythms

·         FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension

·         GLAZIER, JAMES ALEXANDER (contact); DUNN, KENNETH W; KLAUNIG, JAMES E - Development of a Multiscale Mechanistic Simulation of Acetaminophen Induced Liver

·         KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy

·         SANGER, TERENCE D (contact); GISZTER, SIMON F - Multiscale models of neural population control in spinal cord

·         YANKEELOV, THOMAS E (contact); QUARANTA, VITO  - Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer

11)  Mechanistic multiscale models that bridge to the population level to capture more clinical and biological realism for the population

·         BASANTA GUTIERREZ, DAVID  (contact); LYNCH, CONOR C - Multiscale Modeling of Bone Environment Responses to Metastatic Prostate Cancer

·         CORCORAN, TIMOTHY E (contact); PARKER, ROBERT S - Building Multilevel Models of Therapeutic Response in the Lungs

·         GLAZIER, JAMES ALEXANDER (contact); DUNN, KENNETH W; KLAUNIG, JAMES E - Development of a Multiscale Mechanistic Simulation of Acetaminophen Induced Liver

·         LIN, CHING-LONG  - An integrative statistics-guided image-based multi-scale lung model

·         SOBIE, ERIC A (contact); CHRISTINI, DAVID J - Multiscale modeling to map cardiac electrophysiology between species

·         BORON, WALTER F. (contact); TAJKHORSHID, EMAD; SOMERSALO, ERKKI - Multi-scale modeling of gas transport through channels in living cells

12)  Models that generate testable hypotheses regarding the biological underpinnings of behavioral and social phenomena and processes at the individual and population level

13)  Models that describe mechanisms through which “outside-the-skin” factors, such as behavioral stressors, social bonding, parenting behavior, etc., can lead to “inside-the-skin” changes, such as in gene expression, the microbiome, or other factors that affect health or behavior

14)  Models that provide innovative characterizations of interactions between individual-level behaviors, cognition, or affective processes and group-, market-, or population-level outcomes

·         LEE, BRUCE Y - Virtual Population Obesity Prevention (VPOP) Labs: Computational, Multi-Scale Models for Obesity Solutions

15)  Models to explore underlying mechanisms of individual-, community-, or population-level preventive or therapeutic interventions

·         BLUESTEIN, DANNY  - Multiscale Modeling of Blood Flow and Platelet Mediated Thrombosis

·        BAROCAS, VICTOR H (contact); WINKELSTEIN, BETH A - Multiscale Modeling of Facet Capsule Mechanobiology

·         FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension

·         HOLMES, JEFFREY W - Multiscale Models of Cardiac Growth, Remodeling, and Myocardial Infarction

·         KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy

·         LEE, BRUCE Y - Virtual Population Obesity Prevention (VPOP) Labs: Computational, Multi-Scale Models for Obesity Solutions

·         LIN, CHING-LONG  - An integrative statistics-guided image-based multi-scale lung model

·         LYTTON, WILLIAM W - Microconnectomics of neocortex: a multiscale computer model

16)  Novel computational modeling approaches for big data that account for simultaneous sources of data on multiple scales; from biological and physiological measures, to social and psychological variables, and to environmental or contextual or societal level factors

·         BLUESTEIN, DANNY  - Multiscale Modeling of Blood Flow and Platelet Mediated Thrombosis

·         CANNON, WILLIAM R (contact); DUNLAP, JAY C - Multiscale Modeling of Circadian Rhythms

·         LEE, BRUCE Y - Virtual Population Obesity Prevention (VPOP) Labs: Computational, Multi-Scale Models for Obesity Solutions

17)  Multiscale models that characterize the implications of individual-level risks for collective outcomes, or the implications of systemic risks for individual behaviors and outcomes

·         GLAZIER, JAMES ALEXANDER (contact); DUNN, KENNETH W; KLAUNIG, JAMES E - Development of a Multiscale Mechanistic Simulation of Acetaminophen Induced Liver

·         HOLMES, JEFFREY W - Multiscale Models of Cardiac Growth, Remodeling, and Myocardial Infarction

·         LEE, BRUCE Y - Virtual Population Obesity Prevention (VPOP) Labs: Computational, Multi-Scale Models for Obesity Solutions

18)  Predictive multiscale models to improve clinical workflow, standard operating procedures, patient-specific modeling for diagnosis and therapy planning

·        BAROCAS, VICTOR H (contact); WINKELSTEIN, BETH A - Multiscale Modeling of Facet Capsule Mechanobiology

·         CLANCY, COLLEEN E - Predictive multiscale in silico cardio-pharmacology

·         CORCORAN, TIMOTHY E (contact); PARKER, ROBERT S - Building Multilevel Models of Therapeutic Response in the Lungs

·         FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension

·         LAZZI, GIANLUCA  (contact); BERGER, THEODORE W - Predictive modeling of bioelectric activity on mammalian multilayered neuronal st

·         YANKEELOV, THOMAS E (contact); QUARANTA, VITO  - Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer

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