Multiscale Modeling and Viral Pandemics
Physiological Models: Innate and adaptive immune response
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We will consider mathematical models of immune response to viral infections.
Some viruses (e.g. influenza) cause acute infection, some (e.g. HIV, herpesviruses such as CMV and EBV) results in persistent infection and some (hepatitis C and hepatitis B) may generate both outcomes in immune-competent humans. Considerable evidence has shown that differential immune response is a major factor in disease outcome in many viral infections. What features of the virus and which factors of the immune system (both innate and adaptive) affect the outcome? What contributes to the heterogeneity in the outcome?
Is it possible that SARS-CoV-2 establishes a persistent infection in a fraction of otherwise healthy (at the moment of virus introduction) people? Are long-haulers dealing with organ damage after virus clearance or with low-grade reactivation of the virus? The inherent complexity of the immune system requires modeling approaches in order to reveal the molecular and cellular mechanisms that promote unhealthy or non-optimal immune responses. Moreover, the models will be valuable for expediting the discovery and optimization of immunomodulatory treatments of virus infection.
- Identify people working in this area to include a paragraph on their work. (Suspense February 28, 2021)
- Recruit members (assemble the masses)
- Assemble into a directory of researchers. (bibliography for subgroup)
- Identify other subgroups that you should coordinate with
- Prepare a white paper, approx. 5pp in length, excluding references that does the following: (Suspense May 31, 2021)
- Describe the focus of the subgroup, the major problems within it, and the role modeling can play in it
- Describe what models and data are available, and the extent of our biological knowledge, available experimental systems, etc.
- Describe what is needed that does not exist yet: models, data, experimental approaches, etc.
- Outline any action items that could get us there.
- These white papers can form the basis of a collective publication on the topic of multi scale modeling and viral pandemics.
- Catalyze research projects through presentations, exchange of ideas, search for strategic opportunities. (Suspense August 30, 2021)
Guillaume Le Treut
Group Activities and Schedule:
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