Back to Main BRAIN TMM page

LYTTON, WILLIAM W (contact); ANTIC, SRDJAN D Embedded Ensemble Encoding EB022903

We have developed a detailed model of signaling within a rodent Layer 5 neocortical pyramidal cell showing NMDA-mediated plateau potentials lasting 100-400 ms with forward- and back-propagating action potentials. These simulations offer the opportunity to reconceptualize the role of the pyramidal neurons as having complex spatiotemporal dendritic properties with localized UP-states that spread to the soma.

Back to Main BRAIN TMM page