This Notice supports 1) visits of U.S. scientists to conduct collaborative research and/or to acquire advanced research skills in Japanese institutions, 2) Joint workshops to exchange scientific information and to foster collaborations.

Receipt date: September 15, 2010-2012

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Next-Generation Integrated Simulation of Living Matter

Forward Looking Session - The Future of Model Sharing

This panel will discuss the complex technical, sociological and societal challenges to realistic sharing of mathematical and computational models. The discussion will include the review of model sharing efforts of the IMAG Multiscale Modeling (MSM) Consortium over the last three years, a summary of outcomes from the MSM 2007 Model Sharing workshop, and highlight efforts that are developing and efforts that have achieved successful outcomes.

Biological systems are inherently modular but the modules are highly connected, with multiple feedbacks. Automated reconstruction from archived modules requires adherence to standards, the use of ontologies, and computer-recognition of relationships between processes. Even more challenging is the automation of the processes of reducing model complexity for using modules in higher level, more speedily computable versions.

Biological systems are inherently modular but the modules are highly connected, with multiple feedbacks. Automated reconstruction from archived modules requires adherence to standards, the use of ontologies, and computer-recognition of relationships between processes. Even more challenging is the automation of the processes of reducing model complexity for using modules in higher level, more speedily computable versions.

This symposium will focus on modeling of biological systems using single-cells as a natural level of abstraction. Unlike continuum models where cells are represented in the form of density, cell-level modeling provides modelers with deeper insights into biological phenomena and ultimately allows for easy integration with subcellular models. This method is capable of determining single cell phenomena based on more detailed subcellular models than those employed by continuum methods.

• Working groups were too big - not as active as people had hoped. May be more useful to have a smaller group of people (2 -4) that intimately discuss a specific topic highly relevant to their research

• Large groups could be useful as a forum to throw out potential discussion topics that a smaller group could respond to

Multiscale Modeling (MSM)Consortium Mission

• To grow the field of multiscale modeling in biomedical, biological and behavioral systems

• To promote multidisciplinary scientific collaboration among multiscale modelers

• To encourage future generations of multiscale modelers

• To move the field of biological computational modeling forward in the following disciplines
  • predictive models of biology, health and disease
  • bioenergy and bioremediation
  • biomimetics

Agenda for MSM 2008 Consortium Meeting

Tuesday August 5, 2008, 5:30-7pm, Montreal, Canada

Argenteuil Room

1. Recognizing 24 MSM projects, signing of special poster

2. Plans for 2009 meeting - joint US-EU meeting, July 2009(?)

Recent advances in imaging and microscopy techniques have led to a surge in biological data. Different imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI), confocal microscopy, and serial sectioning microscopy (both optical and electron microscopy) have enabled the observation of morphological characteristics of biological systems and organs at multiple spatial and temporal scales (e.g., neuronal networks, vascular networks, airways, and villi).

Recent advances in imaging and microscopy techniques have led to a surge in biological data. Different imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI), confocal microscopy, and serial sectioning microscopy (both optical and electron microscopy) have enabled the observation of morphological characteristics of biological systems and organs at multiple spatial and temporal scales (e.g., neuronal networks, vascular networks, airways, and villi).