This notice of funding opportunity (NOFO) invites applications proposing to establish multi-scale computational models recapitulating dynamic changes associated with aging and Alzheimer’s disease (AD) and AD-related dementias (ADRD). This broad scope encompasses a variety of computational approaches—such as mathematical and computational modeling, image analysis, artificial intelligence, and machine learning—to better understand aging processes and AD/ADRD across molecules, cells and networks, and cognition and behavior.