(Matlab) Adenine nucleotide translocator (ANT)
The primary function of Adenine nucleotide translocator (ANT) is to catalyze ADP/ATP exchange across the inner membrane. Under respiring conditions, ATP4− generated by oxidative phosphorylation is exported to the cytosol for use in cellular activities and ADP3− is imported into the mitochondrial matrix for continuous ATP synthesis. Ant is therefore an ADP3−/ATP4− exchanger. The two reactions involved in the ANT are: 1. (cytoplasm) Creatine Kinase (EC 22.214.171.124) Phosphocreatine + ADP + H+ <-> Creatine + ATP 2. (Mito matrix) ATP Hydrolysis (EC 126.96.36.199) ATP + H2O <-> ADP + Pi + H+ Hydrolysis of ATP. Model generated from The Biochemical Simulation Environment (BISEN).
Figure 1: Potential energy across mito membrane.
Figure 2: Progress curves of ATP and ADP in cytoplasm.
Figure 3: Progress curves of ATP and ADP in mito membrane matrix.
The equations for this model may be viewed opening the Matlab model below.
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Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.