O2 and CO2 exchange between alveolar air and pulmonary capillary and tissue capillary and metabolic reaction with specified Respiratory Quotient
Four-compartment lumped model of recirculation betwee pulmonary alveolus and a oxygen consuming tissue where O2 -> CO2, at chosen RQ. The four compartments are alveolar gas, pulmonary capillary, tissue capillary, and tissue. The Hb binding of O2 and CO2 considers the effects of O2, CO2, pH, Temperature ans 2,3-DPG. (Dash 2010).
The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
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Dash RK, Li Z, and Bassingthwaighte JB. Simultaneous blood-tissue exchange of oxygen, carbon dioxide, bicarbonate, and hydrogen ion. Ann Biomed Eng 34: 1129-1148, 2006. Carlson BE, Anderson JC, Raymond GR, Dash RK, and Bassingthwaighte JB. Modeling oxygen and carbon dioxide transport and exchange using a closed loop circulatory system. In: Oxygen Transport to Tissue XXIX, edited by Kang KA, Harrison DK, and Bruley DF. New York, NY: Springer, 2008, pp 353-360.
Dash RK and Bassingthwaighte JB. Erratum to: Blood HbO2 and HbCO2 dissociation curves at varied O2, CO2, pH, 2,3-DPG and Temperature Levels. Ann Biomed Eng 38(4): 1683-1701, 2010.
Bassingthwaighte JB, Beard DA, Carlson BE, Dash RK, and Vinnakota K. Modeling to link regional myocardial work, metabolism and blood flows. Ann Biomed Eng 40: 2379-2398, 2012.
Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.