AspartateTransferase_BISEN

Model number
0410

Aspartate Aminotransferase reaction. Translated from BISEN generated model.

Description

 Aspartate Aminotransferase (EC 2.6.1.1)
 alpha-Ketogluterate + Aspartate <-> Oxaloacetate + Glutamate

 This reaction catalyzes the reversible transfer of an alpha-amino group between
 aspartate and glutamate and is an important enzyme in amino acid metabolism.

fig 1

Figure 1: Progress curves of the substrates. Circles are output from Matlab version.

Equations

The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

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References
Key terms
TCA
enzyme
BISEN
Cardiac grid
proton
inorganic phosphate
hydrolysis
magnesium
potassium
Gibbs free energy
thermodynamics
Matlab
ketogluterate
Aspartate
glutamate
aspartate transferase
oxaloacetate
Acknowledgements

Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.