Adair's hemoglobin-oxygen dissociation equation expressed in terms of P50 for sheep blood. Compare to two other variations of Adair's equation.
These three models are variations on Adair's original model: shbo2_adair1: A1-A4 in Adair's equation is expressed in terms of P50 for sheep blood. So standard P50 should be 41 mmHg. It should not be used for human blood. For human blood, P50 is about 26.8 mmHg. shbo2_adair2: Oxyhemoglobin dissociation curve computed through Adair's equations A1-A2 in Adair's equation are based on the data from Mathematical Physiology book by Keener and Snyed. shbo2_adair3: Oxyhemoglobin dissociation curve computed through Adair's equations A1-A2 in Adair's equation are based on the data from Roughton et al (1972) paper: Alfred Benzon Symposium IV. Compare and contrast to other HbO2 dissociation calculations such as Hill (model #0028), Severinghaus (#0027), Adair (#0238), Kelman (#0294), and Dash (#0032).
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Adair GS. The hemoglobin system. VI. The oxygen dissociation curve of hemoglobin. J Biol Chem 63: 529-545, 1925. Buerk DG, Bridges EW, A simpified algorithm for computing the variation in oxyhemoglobin saturation with pH, PCO2, T and DPG, Chem Eng Commun, 1985, Vol 47, 113-124 Kelman GR, Digital computer subroutine for the conversion of oxygen tension into saturation. Journal of Applied Physiology, July 1966 21(4), 1375-1376 Keener J and Sneyd J. Mathematical Physiology. New York, NY: Springer-Verlag, 1998, 766 pp. Hill R. Oxygen dissociation curves of muscle hemoglobin. Proc Roy Soc Lond B 120: 472-480, 1936. Roughton FJW, Deland EC, Kernohan JC, and Severinghaus JW. Some recent studies of the oxyhemoglobin dissociation curve of human blood under physiological conditions and the fitting of the Adair equation to the standard curve. In: Oxygen Affinity of Hemoglobin and Red Cell Acid Base Status. Proceedings of the Alfred Benzon Symposium IV Held at the Premises of the Royal Danish Academy of Sciences and Letters, Copenhagen 17-22 May, 1971, edited by Rorth M and Astrup P. Copenhagen: Munksgaard, 1972, p. 73-81. Severinghaus, JW. Simple, accurate equations for human blood 02 dissociation computations. J. Appl. Physiol.:Respirat. Environ. Exercise Physiol. 46(3): 599-602, 1979. Winslow RM, Swenberg M-L, Berger RL, Shrager RI, Luzzana M, Samaja M,and Rossi-Bernardi L. Oxygen equilibrium curve of normal human blood and its evaluation by Adair's equation. J Biol Chem 252: 2331-2337, 1977.
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