Model number

The vascular smooth muscle cell electrophysiology model as developed by Kapela et al, 2008.


  This model presents the vascular smooth muscle cell electrophysiology 
  model as developed by Kapela et al. (J Theor Biol 253:238-260, 2008). 
  The MATLAB code which this JSim version is based on was reproduced from 
  the paper and also from the model code written in Fortran graciously 
  supplied by Kapela and Tsoukias.


The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

Download JSim model project file

Help running a JSim model.

  Kapela A, Bezerianos A and Tsoukias NM., A mathematical model of Ca2+ dynamics
  in rat mesenteric smooth muscle cell: agonist and NO stimulation.
  Journal of Theoretical Biology 253:238-260, 2008.

Key terms
calcium dynamics
gap junctions
ion channels
nitric oxide
arteriol smooth muscle
vascular tone
membrane potential

Please cite in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

Model development and archiving support at provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.